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These molecules are identi-ed via a variety of drug discovery strategies that have been undertaken to blockp53-MDM2/MDMX interactions, or modulate MDM2’s E3 ubiquitin ligaseactivity, and/or inhibit MDM2-mediated ubiquitination of p53 (Table 16.1).However, the main strategies are high-throughput screening (HTS) using bio-chemical, physicochemical and/or cell-based assays, combinatorial chemistryand computational aided drug design including structure-based rational drugdesign and virtual screening. 2001 ).In both studies, RIP was able to track the relation-ship between PEEP and EELV during a series ofPEEP changes from 0 to 8 cm H 2O. Thepotential for PEEP to induce change in EELV inthe ventilated neonate is signi?cantly greater thanfor isolated changes in PIP or TI (Thome et al.1998).
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